唐国涛，男，博士，讲师，硕士生导师。1974年12月生于湖北京山。1993-1997年 湖北中医学院中药系，获医学学士学位。1997-2001年 江苏康缘药业工作。
2001-2004年 湖北中医学院中药学专业，获中药学硕士学位。2006-2010年 复旦大学药学院药剂学专业，获药剂学博士学位。2004年起在药学院任教。主持省市厅级课题6项，在国内外期刊发表论文40余篇，授权专利3项。
主要研究方向：
1.药物化学方向：针对肿瘤微环境中肿瘤血管增生，低氧，糖酵解，低pH值等特征， 以微管蛋白，低氧诱导因子及VEGF，糖酵解相关蛋白酶，pH调节相关蛋白为靶点，通过计算机模拟分子对接，设计合成多靶点肿瘤微环境响应小分子抗肿瘤化合物。
2.新药研究与开发：化学药物合成与制剂的研究开发、中药及其制剂的研究开发（实验室具备中试条件）。
主持或参加科研项目
1.湖南省自然科学基金面上项目，2020JJ4534，含芳基脲结构的三甲氧基黄酮衍生物的合成及抗肿瘤活性研究，2020-2022，5.0万，进行中，主持
2.湖南省教育厅高校创新平台开放基金项目，17K082，肝癌共定位FA-GC-FUA纳米前药用于自杀基因递送及其协同抗肿瘤作用研究，2017.9-2018.12，5.0万，已结题，主持。
3.湖南省教育厅一般项目，13C833，PEG-b-C16酸敏释药聚合物胶束肿瘤靶向给药系统的研究，2014.1-2015.12，1.0万，已结题，主持
4.湖南省中医药管理局课题，201162，脂麻杆抗炎活性成分研究，2012-2013, 1.5万，已结题，主持。
发表论文情况
1.Xueyan Sun; Yijiao Peng; Jingduo Zhao; Zhizhong Xie; Xiaoyong Lei; Guotao Tang（通讯作者). Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors. Bioorganic Chemistry, 2021, 112(104891).
2.Xiong, Runde; Peng, Yijiao; Li, Zhen; Peng, Junmei; Xie, Zhi-Zhong; Lei, Xiao-Yong; He, Dongxiu; Tang, Guotao（通讯作者). Design, synthesis, and biological evaluation of 3 ',4 ',5 '-trimethoxy evodiamine derivatives as potential antitumor agents. Drug Development Research, 2021, 82: 1021-1032.
3.Deng, Xiangping; Pi, Yiyuan; Li, Zhongli; Xiong, Runde; Liu, Juan; Zhao, Jingduo; Xie, Zhizhong; Lei, Xiaoyong; Tang, Guotao（通讯作者). FB-15 inhibits MGC-803 cells growth by regulating energy metabolism. Chemico-Biological Interactions, 2020, 327: 0-109186.
4.Liurenbo; Dengxiangping; Pengyijiao; Fengwanshi;Xiongrunde; Zouyang; Leixiaoyonh; Xiezhizhong; Zhengxin; tangguotao（通讯作者). Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents. Bioorganic Chemistry, 2020, 96(103652): 1-15.
5.Xiangping Deng, Yijiao Peng, Jingduo Zhao, Xiaoyong Lei, Xing Zheng, Zhizhong Xie and Guotao Tang*（通讯作者), Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway, Current Organic Chemistry, 2019, 23, 2945-2959.
7.Xiangping Deng, Renbo Liu, Junjian Li, Zhongli Li, Juan Liu, Runde Xiong, Xiaoyong Lei, Xing Zheng,Zhizhong Xie, Guotao Tang*（通讯作者） Design, synthesis and preliminary biological evaluation of 3′,4′,5′-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents. New Journal of Chemistry, 2019, 43:1874-1884.
8.Shujuan Xiong, Zhe Wanga, Juan Liu, Xiangping Deng, Runde Xiong, Xuan Cao, Zhizhong Xie, Xiaoyong Lei, Yanming Chen, Guotao Tang*（通讯作者） A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy. Colloids and Surfaces B: Biointerfaces, 2019,173 : 346-355.
9.Xiangping Deng, Zhongli Li, Runde Xiong, Juan Liu, Renbo Liu, Junmei Peng, Yanming Chen, Xiaoyong Lei, Xuan Cao, Xing Zheng, Zhizhong Xie*, Guotao Tang*（通讯作者） FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis. Biomedicine & Pharmacotherapy. 2019,109 : 1659–1669.
10.Zhe Wang, Xiangping Deng, Shujuan Xiong, Runde Xiong, Juan Liu, Liu Zou, Xiaoyong Lei, Xuan Cao, Zhizhong Xie, Yanming Chen, Yunmei Liu, Xing Zheng* and Guotao Tang*（通讯作者）. Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents. Nat Prod Res, 2018, 32(24): 2900-2909
11.Liu Zou, Shujuan Xiong, Xiangping Deng, Juan Liu, Runde Xiong, Zhe Wang, Xuan Cao, Yanming Chen, Yu Guo*, Guotao Tang*（通讯作者）. Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats Acta Poloniae Pharmaceutica - Drug Research. 2018,75(6):1305-1312.
12.Zhe Wang, Xiangping Deng, Runde Xiong, Shujuan Xiong, Juan Liu, Xuan Cao, Xiaoyong Lei, Yanming Chen, Xing Zheng* Guotao Tang*（通讯作者）. Design, synthesis and biological evaluation of 3′,4′,5′-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents. MedChemComm, 2018, 9:305-315.
13.Zhe Wang, Xiangping Deng, Jinsong Ding, Wenhu Zhou, Xing Zheng* and Guotao Tang*（通讯作者）. Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review. Int J Pharm, 2018, 535:253-260.
14.Xiangping Deng, Zihao Zhao, Shujuan Xiong, Runde Xiong, Juan Liu, Zhe Wang, Liu Zou, Xiaoyong Lei, Xuan Cao, Zhizhong Xie, Yanming Chen, Xing Zheng, Yunmei Liu* and Guotao Tang*（通讯作者）. Synthesis and evaluation of antitumour activity in vitro and in vivo of chrysin salicylate derivatives. Nat Prod Res, 2018. 32（18）：2178-2186.
15.Xiangping Deng, Zhe Wang, Juan Liu, Shujuan Xiong, Runde Xiong, Xuan Cao, Yanming Chen, Xing Zheng* and Guotao Tang*（通讯作者）. Design, synthesis and biological evaluation of flavonoid salicylate derivatives as potential antitumor agents. RSC Adv, 2017, 7:38171-38178.
联系电话：15873478441 E-mail:tgtzq@163.com
