硕士研究生导师-唐国涛

唐国涛，男，博士，讲师，硕士生导师。1974年12月生于湖北京山。1993-1997年 湖北中医学院中药系，获医学学士学位。1997-2001年 江苏康缘药业工作。

2001-2004年 湖北中医学院中药学专业，获中药学硕士学位。2006-2010年 复旦大学药学院药剂学专业，获药剂学博士学位。2004年起在药学院任教。主持省市厅级课题6项，在国内外期刊发表论文40余篇，授权专利3项。

主要研究方向：

1.药物化学方向：针对肿瘤微环境中肿瘤血管增生，低氧，糖酵解，低pH值等特征， 以微管蛋白，低氧诱导因子及VEGF，糖酵解相关蛋白酶，pH调节相关蛋白为靶点，通过计算机模拟分子对接，设计合成多靶点肿瘤微环境响应小分子抗肿瘤化合物。

2.新药研究与开发：化学药物合成与制剂的研究开发、中药及其制剂的研究开发（实验室具备中试条件）。

主持或参加科研项目

1.湖南省自然科学基金面上项目，2020JJ4534，含芳基脲结构的三甲氧基黄酮衍生物的合成及抗肿瘤活性研究，2020-2022，5.0万，进行中，主持

2.湖南省教育厅高校创新平台开放基金项目，17K082，肝癌共定位FA-GC-FUA纳米前药用于自杀基因递送及其协同抗肿瘤作用研究，2017.9-2018.12，5.0万，已结题，主持。

3.湖南省教育厅一般项目，13C833，PEG-b-C16酸敏释药聚合物胶束肿瘤靶向给药系统的研究，2014.1-2015.12，1.0万，已结题，主持

4.湖南省中医药管理局课题，201162，脂麻杆抗炎活性成分研究，2012-2013, 1.5万，已结题，主持。

发表论文情况

1.Xueyan Sun; Yijiao Peng; Jingduo Zhao; Zhizhong Xie; Xiaoyong Lei; Guotao Tang（通讯作者). Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors. Bioorganic Chemistry, 2021, 112(104891).  

2.Xiong, Runde; Peng, Yijiao; Li, Zhen; Peng, Junmei; Xie, Zhi-Zhong; Lei, Xiao-Yong; He, Dongxiu; Tang, Guotao（通讯作者). Design, synthesis, and biological evaluation of 3 ',4 ',5 '-trimethoxy evodiamine derivatives as potential antitumor agents. Drug Development Research, 2021, 82: 1021-1032.  

3.Deng, Xiangping; Pi, Yiyuan; Li, Zhongli; Xiong, Runde; Liu, Juan; Zhao, Jingduo; Xie, Zhizhong; Lei, Xiaoyong; Tang, Guotao（通讯作者). FB-15 inhibits MGC-803 cells growth by regulating energy metabolism. Chemico-Biological Interactions, 2020, 327: 0-109186.  

4.Liurenbo; Dengxiangping; Pengyijiao; Fengwanshi;Xiongrunde; Zouyang; Leixiaoyonh; Xiezhizhong; Zhengxin; tangguotao（通讯作者). Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents. Bioorganic Chemistry, 2020, 96(103652): 1-15.

5.Xiangping Deng, Yijiao Peng, Jingduo Zhao, Xiaoyong Lei, Xing Zheng, Zhizhong Xie and Guotao Tang*（通讯作者), Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway, Current Organic Chemistry, 2019, 23, 2945-2959.

6.Runde Xiong, Dongxiu He, Xiangping Deng, Juan Liu, Xiaoyong Lei, Zhizhong Xie, Xuan Cao, Yanming Chen, Junmei Peng, Guotao Tang*（通讯作者), Design, synthesis and biological evaluation of tryptamine salicylic acid derivatives as potential antitumor agents. Med. Chem. Commun., 2019, 10, 573–583.

7.Xiangping Deng, Renbo Liu, Junjian Li, Zhongli Li, Juan Liu, Runde Xiong, Xiaoyong Lei, Xing Zheng,Zhizhong Xie, Guotao Tang*（通讯作者） Design, synthesis and preliminary biological evaluation of 3′,4′,5′-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents. New Journal of Chemistry, 2019, 43:1874-1884.

8.Shujuan Xiong, Zhe Wanga, Juan Liu, Xiangping Deng, Runde Xiong, Xuan Cao, Zhizhong Xie, Xiaoyong Lei, Yanming Chen, Guotao Tang*（通讯作者） A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy. Colloids and Surfaces B: Biointerfaces, 2019,173 : 346-355.

9.Xiangping Deng, Zhongli Li, Runde Xiong, Juan Liu, Renbo Liu, Junmei Peng, Yanming Chen, Xiaoyong Lei, Xuan Cao, Xing Zheng, Zhizhong Xie*, Guotao Tang*（通讯作者） FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis. Biomedicine & Pharmacotherapy. 2019,109 : 1659–1669.

10.Zhe Wang, Xiangping Deng, Shujuan Xiong, Runde Xiong, Juan Liu, Liu Zou, Xiaoyong Lei, Xuan Cao, Zhizhong Xie, Yanming Chen, Yunmei Liu, Xing Zheng* and Guotao Tang*（通讯作者）. Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents. Nat Prod Res, 2018, 32(24): 2900-2909

11.Liu Zou, Shujuan Xiong, Xiangping Deng, Juan Liu, Runde Xiong, Zhe Wang, Xuan Cao, Yanming Chen, Yu Guo*, Guotao Tang*（通讯作者）. Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats Acta Poloniae Pharmaceutica - Drug Research. 2018,75(6):1305-1312.

12.Zhe Wang, Xiangping Deng, Runde Xiong, Shujuan Xiong, Juan Liu, Xuan Cao, Xiaoyong Lei, Yanming Chen, Xing Zheng* Guotao Tang*（通讯作者）. Design, synthesis and biological evaluation of 3′,4′,5′-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents. MedChemComm, 2018, 9:305-315.

13.Zhe Wang, Xiangping Deng, Jinsong Ding, Wenhu Zhou, Xing Zheng* and Guotao Tang*（通讯作者）. Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review. Int J Pharm, 2018, 535:253-260.

14.Xiangping Deng, Zihao Zhao, Shujuan Xiong, Runde Xiong, Juan Liu, Zhe Wang, Liu Zou, Xiaoyong Lei, Xuan Cao, Zhizhong Xie, Yanming Chen, Xing Zheng, Yunmei Liu* and Guotao Tang*（通讯作者）. Synthesis and evaluation of antitumour activity in vitro and in vivo of chrysin salicylate derivatives. Nat Prod Res, 2018. 32（18）：2178-2186.

15.Xiangping Deng, Zhe Wang, Juan Liu, Shujuan Xiong, Runde Xiong, Xuan Cao, Yanming Chen, Xing Zheng* and Guotao Tang*（通讯作者）. Design, synthesis and biological evaluation of flavonoid salicylate derivatives as potential antitumor agents. RSC Adv, 2017, 7:38171-38178.

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