李坚，男，博士，南华大学校聘教授，硕士研究生导师。2018年和2023年于中山大学药学院分别获学士学位和博士学位，师从陈新滋院士和熊小峰教授，2023年9月至今，在南华大学药学院从事教学科研工作。主要研究方向为多肽及蛋白质选择性修饰与应用，多肽药物的设计与合成。作为课题负责人主持南华大学博士启动基金1项，参与国家自然科学基金面上项目1项。近年来以第一作者在Chem. Sci.、Sci. China Chem.、Org. Lett.、Chin. Chem. Lett.、J. Med. Chem.等国际期刊发表SCI论文数篇，申请专利一项。
代表性论文
[1]Jian Li, Jun-Jie Deng, Zhibin Yin, Qi-Long Hu, Yang Ge, Zhen-Dong Song, Ying Zhang, Albert S. C. Chan, Huilin Li, and Xiao-Feng Xiong*. Cleavable and tunable cysteine-specific arylation modification by aryl thioethers. Chem. Sci., 2021, 12, 5209-5215.
[2]Jian Li, Qi-Long Hu, Zhendong Song, Albert S. C. Chan*, Xiao-Feng Xiong*. Cleavable Cys labeling directed Lys site-selective stapling and single-site modification. Sci. Chin. Chem., 2022, 65, 1356-1361.
[3]Jian Li, Weihong Lai, Ao Pang, Lu Liu, Lianbao Ye, Xiao-Feng Xiong*. On-resin synthesis of linear aryl thioether containing peptides and in-solution cyclization via cysteine SNAr reaction. Org. Lett., 2022, 24, 1673-1677.
[4]Jian Li, Qi-Long Hu, Xue-Ping Chen, Ke-Qiang Hou, Albert S. C. Chan*, Xiao-Feng Xiong*. Asymmetric synthesis of tetrahydropyran[3,2-c]quinolinones via an organocatalyzed formal [3+3] annulation of quinolinones and MBH 2-naphthoates of nitroolefifin. Chin. Chem. Lett., 2020, 31, 697-700.
[5]Jian Li#, Yang Ge#, Jun-Xiang Huang, Kristian Strømgaard, Xiaolei Zhang, Xiao-Feng Xiong*. Heterotrimeric Gproteins as therapeutic targets in drug discovery. J. Med. Chem. 2020, 63, 5013-5030.
招生方向：药学、药物化学
欢迎有志从事科研工作的研究生、本科生加入课题组！
联系方式：lijian@usc.edu.cn
