药学专业硕士研究生导师-何隆薇

何隆薇，男，教授，博士生导师。2015获湖南大学化学专业博士学位，随后入职济南大学，历任讲师、副教授；2020年加入南华大学药学院，入选南华大学高层次青年优秀人才。研究方向主要包括功能荧光分子设计及生物医学应用，迄今以第一/通讯作者在Chem. Soc. Rev.、Chem. Sci.、ACS Appl. Mater. Interfaces、Anal. Chem.、ACS Sensor.、Chem. Comm.、Front. Bioeng. Biotechnol.、J. Mater. Chem. B、Chem.-Eur. J.等著名国际期刊上共发表30余篇论文，其中一区论文20余篇、高被引论文2篇。主持国家自然科学基金青年项目、湖南省自然科学基金、山东省自然科学基金、国家重点实验室开放基金、南华大学高层次人才项目等。

长期欢迎对本研究方向感兴趣的同学报考本课题组的博士和硕士研究生！联系方式：邮箱helongwei0110@163.com。

一、主持科研项目：

1.国家自然科学基金青年项目：编号21605059；新型单独及连续识别亚硝酰氢（HNO）/一氧化氮（NO）比率单荧光探针的设计、合成及生物成像应用研究；2017/01-2019/12；20万元。

2.湖南省自然科学基金面上项目：编号2022JJ30484；构建高对比度近红外荧光探针用于精准肿瘤手术导航研究；2022.1-2024.12；5万。

3.山东省自然科学博士基金项目：编号ZR2016BB26；基于多信号模式荧光探针区分检测半胱氨酸/高半胱氨酸、谷胱甘肽和硫化氢及生物荧光成像研究；2016/11-2018/11；8万元。

4.化学生物传感与计量学国家重点实验室开放基金：编号2021013；构建高对比度近红外荧光探针及肿瘤手术导航研究；2022.4-2024.4；3万。

5.南华大学高层次人才启动项目：编号201RGC012 /有机小分子荧光探针构建及肿瘤分子影像研究，2020/9-2025/9，300万。

二、代表性论文：

1.Longwei He, Baoli Dong, Yong Liu and Weiying Lin^*,Fluorescent chemosensors manipulated by dual/triple interplaying sensing mechanisms,Chemical Society Reviews, 2016, 45(23): 6449−6461.(Highly Cited Paper，中科院一区Top，IF =60.6)

2.Longwei He,Xueling Yang, Xiuqi Kong, Weiying Lin^*,A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and hydrogen sulfide in living cells,Chemical Science, 2017, 8(9): 6257-6265.(Highly Cited Paper，中科院一区Top，IF = 9.9)

3.ongbin Zhong,Renfeng Jiang,Jiayu Zeng, Xiangyang Gong, Xuefeng Yang,Longwei He,^*Lin Yuan, and Dan Cheng,^*Enhancing the Selectivity of Leucine Aminopeptidase Near-Infrared Fluorescent Probes for Assisting in Surgical Tumor Resection,Analytical Chemistry,2023,95, 2428-2435.

4.Yiteng Ding,Rongbin Zhong,Renfeng Jiang, Xuefeng Yang,Longwei He,^*Lin Yuan, and Dan Cheng,Redox-Reversible Near-Infrared Fluorescent Probe for Imaging of Acute Kidney Oxidative Injury and Remedy,ACS Sensors,2023,8, 914−922.(中科院一区Top，IF = 9.6)

5.Songjiao Li, Peipei Wang, Miantai Ye, Ke Yang, Dan Cheng, Zhiqiang Mao,Longwei He,^*Zhihong Liu, A cysteine-activatable near-infrared fluorescent probe for dual-channel tracking lipid droplets and mitochondria in epilepsy,Analytical Chemistry,2023, Accepted.(中科院一区Top，IF = 8.0)

6.Songjiao Li, Ke Yang, Ying Liu, Peipei Wang, Dan Cheng,^*Longwei He,^*An endoplasmic reticulum-targeted near-infrared probe for monitoring HClO fluctuation in diabetic mice and human blood,Sensors and Actuators: B. Chemical,2023,379, 133253.(中科院一区Top，IF = 9.2)

7.Longwei He,Weiying Lin^*, Qiuyan Xu, Mingguang Ren, Haipeng Wei, Jianyong Wang,A simple and effective “capping” approach to readily tune the fluorescence of near-infrared cyanines,Chemical Science, 2015, 6(8): 4530–4536.(中科院一区Top，IF = 9.9)

8.Longwei He, Yunzhen Yang, Weiying lin^*,Rational design of a rigid fluorophore−molecular rotor-based probe for high signal-to-background ratio detection of sulfur dioxide in viscous system,Analytical Chemistry, 2019, 91(23), 15220−15228.(中科院一区Top，IF =8.0)

9.Longwei He, Xueling Yang, Kaixin Xu and Weiying Lin^*,Improved aromatic substitution-rearrangement-based ratiometric fluorescent cysteine-specific probe and its application of real-time imaging under oxidative stress in living zebrafish,Analytical Chemistry, 2017, 89(17): 9567–9573. (中科院一区Top，IF = 8.0)

10.Longwei He, Xueling Yang, Kaixin Xu, Yunzhen Yang, Weiying lin^*,A multifunctional logic gate by means of a triple-chromophore fluorescent biothiol probe with diverse fluorescence signal patterns,Chemical Communications, 2017, 53(98): 13168-13171.(中科院二区Top，IF = 6.0)Longwei He, Xueling Yang, Kaixin Xu, Weiying Lin^*,A mitochondria-targeted fluorescent probe for imaging endogenous malondialdehyde in HeLa cells and onion tissues,Chemical Communications, 2017, 53(29): 4080-4083.(中科院二区Top，IF = 6.0)

11.Longwei He,Qiuyan Xu, Yong Liu, Haipeng Wei, Yonghe Tang, Weiying Lin^*,Coumarin-based Turn-On fluorescence probe for specific detection of glutathione over cysteine and homocysteine,ACS Applied Materials & Interfaces, 2015, 7(23): 12809−12813.(中科院二区Top，IF =10.3)

12.Longwei He,Weiying Lin^*, Qiuyan Xu, Haipeng Wei，A new strategy to construct FRET platform for ratiometric sensing hydrogen sulfide,Chemical Communications, 2015, 7(8): 12809−12813.(中科院二区Top，IF = 6.0)

13.Longwei He,Weiying Lin^*,Qiuyan Xu, Haipeng Wei,A unique type of pyrrole-based cyanine fluorophores with turn-on and ratiometric fluorescence signals at different pH regions for sensing pH in enzymes and living cells，ACS Applied Materials & Interfaces，2014, 6(24): 22326−22333. (中科院二区Top，IF = 10.3)

14.Xiangyang Gong, Dan Cheng^*, Wei Li^*, Yang Shen, Rong Peng, Ling Shi,^*Longwei He^*, Lin Yuan, A highly selective ratiometric molecular probe for imaging peroxynitrite during drug-induced acute liver injury,Journal of Materials Chemistry B, 2021, 9, 8246–8252. (中科院二区Top，IF = 7.5)

15.Songjiao Li, Peipei Wang, Ke Yang, Ying Liu, Dan Cheng,Longwei He,^*Construction of HClO activated near-infrared fluorescent probe for imaging hepatocellular carcinoma,Analytica Chimica Acta,2023, DOI: 10.1016/j.aca.2023.341009.