一、基本情况
王震，博士，教授、博士生导师，九三学社社员，第十四届全国人大代表，南华大学药学院院长。中组部第十三批“国家海外高层次人才引进计划”青年项目入选者，湖南省卫生健康高层次人才青年骨干人才，甘肃省领军人才，甘肃省杰出青年基金获得者，甘肃省科技专家库收录专家，湖南省药学会湖湘药学先锋奖获得者，青海省“昆仑英才”项目领军人才，衡阳市优秀专家，BMC & BMCL杂志青年编委，Organic & Biomolecular Chemistry杂志优秀审稿人，教育部第五轮学科评估专家，科技部“国家外国专家”项目评审专家，创新创业教育先进个人，多次获得省级研究生毕业论文优秀指导教师和校级本科生优秀论文指导教师称号，获得优秀自费留学生奖学金和第95届日本化学会优秀口头报告奖，受中央统战部邀请参加新中国成立70周年阅兵观礼和中国共产党成立100周年庆祝活动。2006年6月毕业于兰州大学化学化工学院，获得学士学位；2009年9月至2012年7月师从上海有机化学研究所李昂研究员，获得硕士学位；2012年10月至2015年10月就读于东京大学药学院，师从Motomu Kanai教授，获得博士学位。留学期间先后得到Kanai教授的JST-Erato项目助理研究员和日本学术振兴会（JSPS）特聘研究员的支持。自独立工作以来，本着以人为本，为人民健康保驾护航的初心，以新药发现为目标，以厚植独特理论基础的中医药作为原创性新化学实体发现的丰富资源和科学依据，紧扣“新药先导化合物的开发和优化”这一主题，构建了“有机合成新方法促进药物发现”这条主线，开展天然产物化学、药物化学、药物设计和化学生物学研究，围绕神经退行性疾病、肿瘤、病原微生物感染等重大疾病进行新药创制研究，建立了基于表型和基于靶标的新药发现体系，构建了涵盖分子靶标发现、靶标确认、先导化合物优化、成药性优化等全面系统的药物开发模式。开发了多批具有自主知识产权，可规模化生产的具备深入研究价值的候选化合物，有多个化合物正在进行临床前或临床研究。已形成以下研究特色与优势：①聚焦天然活性分子骨架高效构筑的合成方法学研究；②紧扣中医药振兴发展的国家战略，开展基于吴茱萸碱等传统中药活性分子的药物发现；③基于靶向蛋白降解策略，对“难成药”靶点进行小分子药物干预；④揭示调控线粒体稳态治疗神经退行性疾病的全新药靶及其小分子药物开发。
到目前为止，王震教授已主持多项科研项目，发现多个具有开发价值的先导化合物，在国际一流期刊上发表科研论文121篇（SCI论文118篇， IF >10：8篇，JCR一区85篇，JCR二区20篇，JCR三区10篇，JCR四区3篇，中文核心2篇，他引2251余次，单篇最高引223次，H-index为24）及申请专利27项（授权13项，转让1项），并参编专著三部/教材一本。兼任全国青年联合会第十二/十三届委员、中华医学会医学科学研究管理学分会第九届委员、中国青年科技工作者协会第六届理事、湖南省九三学社委员、湖南省欧美同学会常务理事、甘肃省青年联合会第十届常委、衡阳市九三学社副主委、衡阳市政协委员、九三学社南华大学工委主委。
Email: zhenw@usc.edu.cn
二、研究领域
神经退行性疾病、肿瘤、病原微生物感染等重大疾病的新药创制
三、工作及学习经历
2024/04-目前 南华大学药学院，院长
2021/07-2024/04 南华大学衡阳医学院，副院长（正处级）
2020/04-2024/04 南华大学衡阳医学院药学院，教授
2015/09-2020/04 国家海外高层次人才引进计划青年项目入选者，兰州大学药学院/兰州大学化学化工学院功能有机分子化学国家重点实验室，教授，博士生导师
2015/04-2015/10 JSPS（日本学术振兴会），特聘研究员（DC2）
2013/04-2015/03 东京大学（Motomu Kanai实验室），助理研究员
2012/07-2012/10 上海有机化学研究所氟化学重点实验室（张新刚实验室），助理研究员
2007/08-2008/07 百灵威技术有限公司，助理研究员
2006/07-2007/06 江苏豪森药业有限公司，助理研究员
2012/10-2015/09 东京大学药学院，博士
2009/09-2012/07 中国科学研究院上海有机化学研究所，硕士
2002/09-2006/07 兰州大学化学化工学院，学士
四、社会兼职
中华医学会医学科学研究管理学分会第九届委员
南华大学附属第一医院兼职教授
湖南省药学会第15届理事
兰州市第二人民医院外聘专家
中国科学院藏药研究重点实验室客座研究员
中国科学院近代物理研究所客座研究员
五、教学工作
从事药物化学课程本科课程，指导学生开展的各类创新创业项目主要包括：甘肃省“挑战者杯”1项（省三等奖），兰州大学“挑战杯”项目2项（分别获得二等奖和三等奖），“国创”项目3项（一项结题被评为优秀，两项中期答辩被评为优秀），“校创”项目4项（两项结题被评为校优秀），“萃英创新基金”1项，化工院创新项目1项，已发表SCI论文多篇，通过这些项目的开展，培养了一批热爱科研的优秀学生，其中两人申请到世界知名学府日本理化技术研究所的侯召明课题组继续深造和一人已申请到北海道大学继续攻读研究生，其余学生大部分参加了我校的“优培计划”或者保送研究生，继续在王震课题组攻读研究生，为我院选留优秀学生做出积极的努力。王震教授获得2017年“挑战杯”兰州大学大学生课外学术科技作品优秀指导教师、2016年兰州大学学生创新创业行动计划优秀指导教师和兰州大学2016-2017学年创新创业教育先进个人的称号。
教改课题：地方高校药学专业研究生“筑梦+逐梦”式国际化人才培养模式的探索与实践（重点项目，5.0万元）；湖南省普通高等学校教学改革研究：药学类专业大学生创新创业教育的发展模式研究（普通教育 重点项目，HNJG-20230580）3.0万元。
六、承担课题
1. 湖南省卫生健康高层次人才重大科研专项：MTDls导向的新型抗AD药物发现及其作用机制研究 （2023.10.31-2027.10.30, 20230410）
2. 湖南省面上基金项目：基于合并法多靶点配体药物设计策略的新型抗AD药物分子的发现 （2023.01.01-2025.12.31，2023JJ30527）
3. 青海省“昆仑英才·高端创新创业人才”项目领军人才项目：（2024.01.01-2026.12.31）湖南省卫生健康高层次人才青年骨干人才项目（2022.05-2027.05）
4. 甘肃省杰出青年基金项目：Lycoplanine A的全合成及抗帕金森病活性研究(2020.11.01-2023.10.31, 20JR5RA304)
5. 兰州市科技发展计划项目——新冠肺炎防控技术研究项目：一种治疗新冠肺炎药物的研发（2020.04-2022.04, 2020-XG-34）
6. 青海省重点研发与转化计划项目：藏药角茴香中抗炎药物候选分子的结构优化与新药临床前研究 (202002040061, 2020.01.01-2022.12.31)
7. 甘肃省极端环境微生物资源与工程重点实验室开放基金项目：深海天然产物Chrysamide B衍生物的设计合成及其抗胃癌活性和作用机制研究 (2020.01.01-2021.12.31)
8. “中央高校基本科研业务费专项资金”科研创新团队建设项目：新型含硫药物的设计合成与抗炎/抗肿瘤活性评价(2019.01.01-2020.12.30, lzujbky-2019-ct08)
9. 青海省自然科学基金面上项目：藏药尼泊尔黄堇抗胃溃疡机制及活性单体的分离合成研究 (2019.01.01-2021.12.31, 2019-ZJ-907)
10. 青海省院藏药研究重点实验室开放课题：细果角茴香活性成分合成及修饰改造(2018.11.01-2019.11.01)
11. 国家海外高层次人才引进计划青年项目 (2017-2020)
12. 中央高校基本科研业务费：金属钯催化的碳氢键活化和环氧乙烷类化合物的偶联新反应开发和应用 (2016.01.01-2017.06.30, lzujbky-2016-153)
13. 甘肃省留学人员科技活动择优资助项目：具有抗癌活性的Duocarmycin家族天然产物的全合成研究 (2016.10.09-2017.06.30, 20161228)
14. 兰州大学科研启动经费项目
七、代表性文章
1) Wang, Z. (第一作者); Ni, J. Z.; Kuninobu, Y.* and Kanai, M.* “Copper-Catalyzed Intramolecular C(sp3)-H and C(sp2)-H Amidation by Oxidative Cyclization” Angew. Chem. Int. Edit. 2014, 53, 3496；Angew. Chem. 2014，126，3564； [highlighted in Synfacts 2014, 10, 0570].
2) Wang, Z. (第一作者); Kuninobu, Y.* and Kanai, M.* “Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C-H Bond Activation” J. Am. Chem. Soc. 2015, 137, 6140. [JACS Most Read top 5 Articles in May and June, 2015].
3) Bian, M.;# Wang, Z.;# (共同第一作者) Xiong, X. C.; Sun, Y.; Matera, C.; Nicolaou, K. C.* and Li, A.* “Total Syntheses of Anominine and Tubingensin A” J. Am. Chem. Soc. 2012, 134, 8078. [JACS Most Read Articles in 12 months (Aug. 2011-July 2012); highlighted in Synfacts 2012, 8, 814 and Organic Chemistry Portal].
4) Wang, H. H.;# Wang, X. D.;# Yin, G. F.; Zeng, Y. F.; Chen, J. J.* and Wang, Z.* (通讯作者) “Recent Advances in Transition-Metal-Catalyzed C-H Alkylation with Three-Membered Rings” ACS Catal. 2022, 12, 2330.
5) Yang, Y. H.;# Gao, W. W.;# Wang, Y. Q.; Wang, X. D.; Cao, F.; Shi, T.* and Wang, Z.* (通讯作者) “Recent Advances in Copper Promoted Inert C(sp3)-H Functionalization.” ACS Catal. 2021, 11, 967.
6) Wang, Y. Q.;# Deng, J. D.;# Chen, J. H.; Cao, F.; Hou, Y. S.; Yang, Y. H.; Deng, X. M.; Yang, J. R.; Wu, L. X.; Shao, X. F.; Shi, T.* and Wang, Z.* (通讯作者) “Dechalcogenization of Aryl Dichalcogenides to Synthesize Aryl Chalcogenides via Copper Catalysis” ACS Catal. 2020, 10, 2707.
7) Zou, J. X.;# Chen, J. H.;# Shi, T.;#, * Hou, Y. S.; Cao, F.; Wang, Y. Q.; Wang, X. D.; Jia, Z.; Zhao, Q. Y. and Wang, Z.* (通讯作者) “Phthalimide-Carried Disulfur Transfer to Synthesize Unsymmetrical Disulfanes via Copper Catalysis” ACS Catal. 2019, 9, 11426.
8) Li, J. F.;# Wang, X. D.;# Zhang, H. H.; Hu, X. L.; Peng, X.; Jiang, W. F.; Zhuo, L. S.; Peng, Y.; Zeng, G.; Wang, Z. (通讯作者) “Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future” Med. Res. Rev. 2024, 1.
9) He, C. Y.; Wang, Z.; Wu, C. Z.; Qing, F. L. and Zhang, X. G.* “Pd-Catalyzed Oxidative Cross-Coupling between Two Electron Rich Heteroarenes” Chem. Sci. 2013, 4, 3508.
10) Jian, L.; # Chen, J. J.;# Hu, Q. L.; Wang, Z.* (通讯作者) and Xiong, X. F. * “Recent progress of chemical methods for lysine site-selective modification of peptides and proteins” Chin. Chem. Lett. 2024, 6, 110126.
11) Li, J. F. #; Hu, X. L. #; Zhang, H. H.; Peng, Y.; Li, S.; Xiong, Y. X.; Jiang, W. F.* and Wang, Z.* (通讯作者) “N-2-(Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression” J. Med. Chem. 2022, 65, 10481.
12) Lei, F.;# Xiong, Y. X.;# Wang, Y. Q.; Zhang, H. H.; Liang, Z. Y.; Li, J. F.; Feng, Y. Y.; Hao, X. Y.* and Wang, Z.* (通讯作者) “Design, Synthesis, and Biological Evaluation of Novel Evodiamine Derivatives as Potential Antihepatocellular Carcinoma Agents” J. Med. Chem. 2022, 65, 7975.
13) Wei, X. Z.;# Zhang, X.;# Peng, Y.; Wu, J, B.; Mo, H. X.; An, Z. G.; Deng, X. Y.; Peng, Y.; Liu, L. Y.; Jiang, W. F.; Chen, J. J.; Hu, Z. C.;* Wang, Z.* and Zhuo, L. S.* “Identification of a Novel 10-hydroxyevodiamine Prodrug as a Potent Topoisomerase Inhibitor with Improved Aqueous Solubility for Treatment of Hepatocellular Carcinoma.” Eur. J. Med. Chem. 2024, 279, 116807.
14) Wu, G. P.;# Li, B.;# Wei, X. Z.; Chen, Y. X.; Zhao, Y. T.; Peng, Y.; Su, J. H.; Hu, Z. C.; Zhuo, L. S.; Tian, Y.;* Wang, Z.* (通讯作者) and Peng, X.* “Design, synthesis and biological evaluation of N-salicyloyl tryptamine derivatives as multifunctional neuroprotectants for the treatment of ischemic stroke” Eur. J. Med. Chem. 2024, 278, 116795.
15) Long, L.;# Xu, J. C.;# Qi, X. W.;# Pen, Y.; Wang, C. K.; Jiang, W. F.; Peng, X.; Hu, Z. C.; Yi, W. J.; Xie, L. M.; Lei, X. Y.; Wang, Z.* (通讯作者) and Zhuo, L. S.*“Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer” Eur. J. Med. Chem. 2024, 273, 116500.
16) Wang, Y. Q.; # Long, L.; # Zhuo, L. S.; Zhang, H. H.; Luo, T.; Deng, J. D.; Wang, Y. Y.; Li, Z.; Wang, Z.* (通讯作者) and Peng, X.* “Design, Synthesis, and Biological Evaluation of 1-styrenyl Isoquinoline Derivatives for Anti-hepatocellular Carcinoma Activity and Effect on Mitochondria” Eur. J. Med. Chem. 2023, 256, 115420.
17) Deng, J. D#; Long, L. #; Peng, X.; Jiang, W. F.; Peng, Y.; Zhang, X.; Zhao, Y. T.; Tian, Y.; Wang, Z.* and Zhuo, L. S.* “N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents” Eur. J. Med. Chem. 2023, 255, 115366.
18) Wang, Z. #,* (共同第一作者，通讯作者); Xiong, Y. X.;# Peng, Y.; Zhang, X.; Li, S.; Peng, Y.; Peng, X.; Zhuo, L. S.* and Jiang, W. F.* “Natural product evodiamine-inspired medicinal chemistry: Anticancer activity, structural optimization and structure-activity relationship” Eur. J. Med. Chem. 2023, 247, 115031.
19) Zhang, H. H.;# Peng, Y.;# Zhuo, L. S.; Wang, Y. Y.; Zeng, G.; Wang, S. Z.; Long, L.; Li, X. L.* and Wang, Z.* (通讯作者) “Recent Advance on Pleiotropic Cholinesterase Inhibitors Bearing Amyloid Modulation Efficacy” Eur. J. Med. Chem. 2022, 242, 114695.
20) Zhang, H. H.;# Wang, Y. Y.;# Wang, Y. Q.; Li, X. L.;* Wang, S. Z.* and Wang, Z.* (通讯作者) “Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease” Eur. J. Med. Chem. 2022, 240, 114606.
21) Hu, X. L.; # Li, J. F.; # Zhang, H. H.; Yu, Q. W.; Wang, Y. Y.; Li, X. L.; Long, L.; Jiang, W. F. * and Wang, Z.* (通讯作者) “Discovery of Dual Inhibitors of Topoisomerase I and Cyclooxygenase-2 for Colon Cancer Therapy” Eur. J. Med. Chem. 2022, 240, 114560.
22) Liang, Z. Y.;# Wang, Y. Q.;# Zhang, H. H.; Deng, J. D.; Lei, F.; Li, J. F.; Shi, T.; Wang, S. Z.;* Li, R. H.* and Wang, Z.* (通讯作者) “Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy” Eur. J. Med. Chem. 2022, 239, 114530,
23) Deng, X. M.;# Luo, T.;# Zhang, X.; Li, Y. H.; Xie, L. M.; Jiang, W. F.; Liu, L. Y.* and Wang, Z.* (通讯作者) “Design, Synthesis and Biological Evaluation of 3-Arylisoquinoline Derivatives as Topoisomerase I and II Dual Inhibitors for the Therapy of Liver Cancer” Eur. J. Med. Chem. 2022, 237, 114376.
24) Liu, D.;# Zhang, H. H.;# Wang, Y. Y.; Liu, W. C.; Yin, G. F.; Wang, D. G.; Li, J. F.; Shi, T. and Wang, Z.* (通讯作者) “Design, Synthesis, and Biological Evaluation of Carbamate Derivatives of N-salicyloyl Tryptamine as Multifunctional Agents for the Treatment of Alzheimer's Disease” Eur. J. Med. Chem. 2022, 229, 114044.
25) Deng, X. M.;# Luo, T.;# Li, Z.;# Wen, H. X.; Zhang, H. H.; Yang, X. Y.; Lei, F.; Liu, D.; Shi, T.; Zhao, Q. Y. and Wang, Z.* (通讯作者) “Design, Synthesis and Anti-Hepatocellular Carcinoma Activity of 3-Arylisoquinoline Alkaloids” Eur. J. Med. Chem. 2022, 228, 113985.
26) Liang, Z. Y.;# Lei, F.;# Deng, J. D.; Zhang, H. H.; Wang, Y. Q.; Li, J. F.; Shi, T.; Yang, X. Y.* and Wang, Z.* (通讯作者) “Design, Synthesis and Bioactivity Evaluation of Novel Evodiamine Derivatives with Excellent Potency against Gastric Cancer” Eur. J. Med. Chem. 2022, 228, 113960.
27) Lu, Y. M.;# Feng, Y. Y.;# Li, Z.; Li, J. F.; Zhang, H. H.; Hu, X. L.; Jiang, W. F.; Shi, T. and Wang, Z.* (通讯作者) “Novel Piperazine Based Benzamide Derivatives as Potential Anti-Glioblastoma Agents Inhibiting Cell Proliferation and Cell Cycle Progression” Eur. J. Med. Chem. 2022, 227, 113908.
28) Feng, Y. Y.;# Lu, Y. M.;# Li, J. F.;# Zhang, H. H.; Li, Z.; Feng, H. Z.; Deng, X. M.; Liu, D.; Shi, T.; Jiang, W. F.; He, Y. X.;* Zhang, J.* and Wang, Z.* (通讯作者) “Design, Synthesis and Biological Evaluation of Novel o-Aminobenzamide Derivatives as Potential Anti-Gastric Cancer Agents in Vitro and in Vivo” Eur. J. Med. Chem. 2022, 227, 113888.
29) Li, J. F.;# Hu, X. L.;# Luo, T.; Lu, Y. M.; Feng, Y. Y.; Zhang, H. H.; Liu, D.; Fan, X. H.; Wang, Y. Q.; Jiang, L. M.; Wang, Y. Y.; Hao, X. Y.; Shi, T.* and Wang, Z.* (通讯作者) “N-2-(phenylamino) Benzamide Derivatives as Novel Anti-Glioblastoma Agents: Synthesis and Biological Evaluation” Eur. J. Med. Chem. 2021, 226, 113817.
30) Fan, X. H.;# Li, J. F.;# Long, L.;# Shi, T.;* Liu, D.; Tan, W.; Zhang, H. H.; Wu, X. Y.; Lei, X. Y.* and Wang, Z.* (通讯作者) “Design, Synthesis and Biological Evaluation of N-anthraniloyl Tryptamine Derivatives as Pleiotropic Molecules for the Therapy of Malignant Glioma” Eur. J. Med. Chem. 2021, 222, 113564.
31) Ma, S. M.;# Zhu, L. Q.;# Fan, X. H.;# Luo, T.; Liu, D.; Liang, Z. Y.; Hu, X. L.; Shi, T.;* Tan, W.* and Wang, Z.* (通讯作者) “Melatonin Derivatives Combat with Inflammation-related Cancer by Targeting the Main Culprit STAT3” Eur. J. Med. Chem. 2021, 211, 113027.
32) Zhang, H. H.;# Bai, Z. J.;# Zhu, L. Q.;# Liang, Y.; Fan, X. H.; Li, J. F.; Wen, H. X.; Shi, T.;* Zhao, Q. Y.* and Wang, Z.* (通讯作者) “Hydrogen Sulfide Donors: Therapeutic Potential in Anti-Atherosclerosis” Eur. J. Med. Chem. 2020, 205, 112665.
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110) Wang, X. D.;# Wang, H. H.;# Wu, X.;# Yu, T. Q.; Gao, W. W.; Shi, T.; Peng, X.; He, D.* and Wang, Z.* (通讯作者) “Total Synthesis of (+)-Mintlactone and (–)-Isomintlactone via SmI2-Induced Radical Cyclization” Synlett. 2017, 28,1660.
111) Wang, Z. (第一作者); Kuninobu, Y.* and Kanai, M.* “Molybdenum-Mediated Desulfurization of Thiols and Disulfides” Synlett. 2014, 25, 1869.
112) Liu, S. Z.; Li, J.; Xue, C. G.; Xu, X. T.;* Lei, L. S.; Huo, C. Y.; Wang, Z. and Wang, S. H.;* “Copper-Promoted Cyanation of Aryl Iodides with N,N-Dimethyl Aminomalononitrile” Tetrahedron Lett. 2021, 65, 152749.
113) Yu, T. Q.;# Hou, Y. S.;# Jiang, Y.;# Xu, W. X.;# Shi, T.; Wu, X.; Zhang, J. C.; He, D.* and Wang, Z.* (通讯作者) “KBr-Catalyzed N-S Bond Formation via Oxidative Dehydrogenation” Tetrahedron Lett. 2017, 58, 2084.
114) Luo, T.;# Deng, X. M.;# Li, Z.; Liu, D.; Weng, X.; and Wang, Z.* (通讯作者) “Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum” Photochem. Lett. 2022, 51, 119.
115) Liu, S. Z.; Cui, M. Y.; Wang, B. W.; Hu, C. M.; Zheng, Y. Y.; Li, J.; Xu, X. T.;* Wang, Z. and Wang, S. H.* “Triethyl Amine-Promoted Cyclization Reaction between Cyclopropenone and alpha-Halogenated Hydroxamate for the Synthesis of Polysubstituted 6H-1,3-Oxazin-6-one” Chin. J. Org. Chem. 2021, 41, 1622.
116) Duan, X. Y.; Liu, X. F.; Dong, Y.; Yang, J.; Zhang, J.; He, S. J.; Yang, F. T.; Wang, Z. and Dong, Y. M.* “A Green HPLC Method for Determination of Nine Sulfonamides in Milk and Beef, and Its Greenness Assessment with Analytical Eco-Scale and Greenness Profile” J. AOAC Int. 2020, 103, 1181.
117) Hu, C. H.; Wei, D. D.; Sun, X. F.; Lin, R. L.; Hu, M. M.; Tang, L.; Wang, Z.; He, D.; “Synthesis, Crystal Structure, Antitumor Activities and Docking Study of 1-(2-(1H-Indol-3-yl)ethyl) -3-(2-methoxyphenyl)urea” Chin. J. Struct. Chem. 2018, 37, 393.
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120) 梁妍, 周翔, 郭建钊, 张梅, 江红格, 付晨青, 付运星, 石紫薇, 刘宇, 辛志君, 陆锡宏, 梁剑平, 郝宝成, 李雪虎*, 王震* (通讯作者) 青蒿新品种 “科蒿 1 号” 的选育研究; 中国中药杂志，2019, 44, 5363.
121) 梁妍, 宋向东, 谢宗秀, 刘宇, 郝宝成, 王震, 王保海*, 梁剑平; 疯草内生真菌研究进展; 动物医学进展，2020, 41, 106.
八、申请发明专利
1. 王震，谭雯，李俊芳，邓杰丹，张红花. 一种吴茱萸生物碱衍生物及其合成方法和应用：中国，ZL201910085249.X [P]. 2021-06-29. 授权-高价值发明专利
2. 王震，张红花，邓杰丹，梁妍，石桃，李俊芳. 一种吴茱萸碱衍生物在制备治疗浅表真菌感染药物中的应用：中国，ZL202111134080.6 [P]. 2023-04-14. 授权
3. 王震，刘林义，李博，彭颖，曾要富，彭雪，陈劲进，王姝之，卓林胜，李霜，彭艳，熊永霞. 一种吴茱萸碱衍生物的制备方法，中国，ZL202210997815.6 [P]. 2024-08-13. 授权
4. 王震，张红花，刘丹，王玉英，李俊芳，石桃. 一种苯甲酸色胺衍生物及其制备与应用：中国，ZL202110856721.2 [P]. 2023-07-07. 授权
5. 王震，张红花，刘丹，石桃，王玉英，李俊芳. 一种氨基甲酸酯类邻氨基苯甲酸色胺衍生物及其制备与应用：中国，ZL202110798096.0 [P]. 2023-03-14. 授权
6. 王震，范晓红，石桃，李俊芳，胡晓玲. 一种色胺水杨酸类化合物及其制备和应用：中国，ZL202011093086.9 [P]. 2024-03-19. 授权
7. 王震，谢黎明，胡晓玲，张茜，石桃，李俊芳，彭燕，王雨晴，王玉英. 一种托灭酸类衍生物及其制备与应用：中国，ZL202210341962.8 [P]. 2024-06-14. 授权
8. 王震，石桃，冯益悦，卢莹美，李俊芳，张红花. 一种含叔胺的邻氨基苯甲酰胺类化合物及其制备与应用：中国，ZL202110382738.9 [P]. 2022-07-19. 授权
9. 王震，石桃，张红花，卢莹美，冯益悦，李俊芳. 一种基于恩替诺特骨架的邻氨基苯甲酰胺类化合物及其制备与应用：中国，ZL202110382954.3 [P]. 2022-07-05. 授权
10. 王震，石桃，李俊芳，张红花，卢莹美，冯益悦. 一种基于伏立诺他骨架的邻氨基苯甲酰胺类化合物及其制备与应用：中国，ZL202110382959.6 [P]. 2023-01-06. 授权
11. 王震，朱龙青，范晓红，李俊芳，石桃，张红花，唐爱民。一种具有抗肿瘤活性的chrysamides B衍生物及其制备和应用：ZL202010188913.6 [P]. 2022-08-30. 授权
12. 王震，陈金鸿，彭雪，侯永胜，邓杰丹. 含硝基天然产物chrysamides B合成方法及其非对映异构体-化合物：中国，ZL201810669903.7 [P]. 2021-08-24. 授权
13. 王震，谢黎明，张茜，李昭，冯益悦，卢莹美. 一种1-苯乙烯基异喹啉衍生物及其制备与应用，中国，ZL202210026209.X [P]. 2024-04-17. 授权
14. 王震，贺春阳，曾要富，江伟凡，李学林，龙鳞，一种氟芳烃氨基酸及其合成方法：中国，ZL202111472717.2 [P]. 2023-06-23. 授权
15. 王震，石桃，朱龙青，李俊芳，范晓红，张红花，冯益悦，卢莹美，王晓东，唐爱民. 一种新型哌嗪类化合物及其制备方法和应用：中国，ZL201911297009.2 [P]. 2023-5-26. 授权
16. 王震，刘林义，邓雪梅，罗添，张茜，李跃华，谢黎明，江伟凡. 一种3-芳基异喹啉衍生物及其制备与应用，中国，CN202210158124.7 [P]. 2023-08-22. 授权
17. 梁剑平，刘宇，王震，梁妍，郝宝成，王学红，郭文柱，赵凤舞，杨珍，贾忠，张新刚，陈虹. 一种甘草次酸酯及其制备方法和在制备抗病毒药物中的应用：中国，ZL201810205157.6 [P]. 2019-12-31. 授权-权力转移
18. 王震，彭颖，廖红伍，曾国，周玉生，张茜，孙守元，江金环，江伟凡，刘林义，陈劲进，卓林胜，米静，李博，李志毅. 一种吴茱萸碱衍生物抗浅部真菌乳膏的制备方法，中国，CN202211163250.8 [P]. 2022-09-23. 实质审查
19. 王震，彭颖，曾国，廖红伍，米静，张茜，赵贵全，江伟凡，卓林胜，刘林义，陈劲进，李国华，龙灵馨，李志毅. 一种吴茱萸碱衍生物抗浅部真菌固体脂质纳米粒凝胶的制备方法，中国，CN202211163538.5 [P]. 2022-09-23. 实质审查
20. 王震，陈劲进，李霜，江伟凡，刘林义，李博，曾要富，彭雪，王姝之，卓林胜，熊永霞，彭艳. 一种邻吡咯烷基苯甲酰胺类化合物的制备方法. 中国，CN202211450418.3. 实质审查
21. 王震，石桃，范晓红，李俊芳. 一种新型色胺衍生物及其制备方法和应用：中国，CN201911145064.X [P]. 2019-11-12. 实质审查
22. 王震，侯永胜，范晓红，李俊芳，邓杰丹. 一种1，3-苯并噻嗪酮类化合物及其合成方法和应用：中国，CN201811319974.0 [P]. 2018-11-07. 实质审查
23. 王震，彭雪，王姝之，卓林胜，江伟凡，陈劲进，赵雨婷，巫根平，曹柳丽，吴坤，赵亚蓉，曾晶. 一种 N-乙酰色胺类化合物、组合物和应用：中国，CN202310876756.1实质审查
24. 王震，卓林胜，江伟凡，彭雪，陈劲进，曾要富，王姝之，刘林义，张宇，陈淑婷，韦秀珍，李博. 一种水溶性吴茱萸碱衍生物和应用：中国，CN202311104152.1实质审查
25. 王震，江伟凡，彭雪，陈劲进，卓林胜，王姝之，曾要富，刘林义，张宇，韦秀珍，李博，陈淑婷. 一种含酯基取代吴茱萸碱衍生物、制备方法和应用：中国CN202311104165.9实质审查
26. 王震，石桃，李俊芳，张红花，王晓东. 一种N-芳基邻氨基苯甲酰胺类化合物及其制备和应用：中国，CN202110311265.3 [P]. 2021-03-24. 实质审查
27. 王震，张红花，邓杰丹，梁子怡，雷芳，石桃. 一种吴茱萸碱衍生物及其制备和应用：中国，CN202111133320.0 [P]. 2021-09-27. 实质审查
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