一、基本情况
贺宇航，生物化学与分子生物学博士；校聘副教授。主要从事多肽的药物化学研究和多肽生物医学材料研究。在J. Med. Chem., Eur. J. Med. Chem., ACS Nano, Sci. Adv.等国际权威杂志发表科研论文7篇。授权专利2项。
Email: heyh@usc.edu.cn
二、研究领域
1. 多肽药物的发现、设计及结构优化研究。
2. 多肽生物医学材料的设计及其应用。
三、工作及学习经历
2025/12-至今，南华大学，药学院，校聘副教授
2018/9-2025/9，兰州大学，基础医学院，博士
2014/9-2018/6，西南大学，园艺园林学院，本科
四、代表性文章
1) He, Yuhang; Su, Jie; Li, Min; Fareed, Muhammad S.; Ren, Yixuan; Wang, Panpan; Wang, Zhaopeng; Wan, Daicao; Ma, Ting; Yan, Wenjin;* Zhang, Hailong;* Wang, Kairong.* Discovery of Cationic Lugdunin Derivatives with Membrane-Disrupting Activity against Resistant Bacteria via Radical Reactions and Amino Acid Mutations. J Med Chem. 2025, 68 (5), 5699-5718.
2) He, Yuhang; Li, Min; Su, Jie; Ren, Yixuan; Fareed, Muhammad S.; Shen, Zhiqiang; Wang, Panpan; Ji, Qingxian; Wang, Zhaopeng; Wan, Daicao; Ting; Yan, Jiexi;* Wang, Kairong.* Expanding the Antimicrobial Spectrum of Lugdunin: Discovery of Multi-Cationic Derivatives of Lugdunin with Antimicrobial Activity against Gram-Positive and Gram-Negative Bacteria. Eur J Med Chem 2025, 118078.
3) Wen, Qi;# He, Yuhang;# Chi, Jiaying;# Wang, Luyao; Ren, Yixuan; Niu, Xiaoke; Yang, Yanqing; Chen, Kang; Zhu, Qi; Lin, Juncheng; Xiang, Yanghui; Xie, Junqiu; Chen, Wenteng; Yu, Yongping; Wang, Baohong; Wang, Bo; Zhang, Ying; Lu, Chao; Wang, Kairong;* Teng, Peng;* Zhou, Ruhong.* Naturally inspired chimeric quinolone derivatives to reverse bacterial drug resistance. Eur J Med Chem 2025, 289, 117496.
4) Su, Jie;# He, Yuhang;# Li, Min;# Shen, Zhiqiang; Ji, Qingxian; Ren, Yixuan; Fareed, Muhammad Subaan; Wang, Kairong.* Discovery of adamantane-containing small-molecule peptidomimetics with membrane-disrupting activity for combating drug-resistant Bacteria. Bioorg Chem 2025, 165, 108990.
5) Sheng, Hongwei;# Zhou, Jingjing;# Li, Bo; He, Yuhang; Zhang, Xuetao; Liang, Jie; Zhou, Jinyuan; Su, Qing; Xie, Erqing; Lan, Wei; Wang,* Kairong;* Yu, Cunjiang.* A thin, deformable, high-performance supercapacitor implant that can be biodegraded and bioabsorbed within an animal body. Sci Adv 2021, 7 (2), eabe3097.
6) Zhou, Jingjing; Zhang, Hanru; Fareed, Muhammad Subaan; He, Yuhang; Lu, Yaqi; Yang, Changyan; Wang, Zhaopeng; Su, Jie; Wang, Panpan; Yan, Wenjin;* Wang, Kairong.* An Injectable Peptide Hydrogel Constructed of Natural Antimicrobial Peptide J-1 and ADP Shows Anti-Infection, Hemostasis, and Antiadhesion Efficacy. ACS Nano 2022, 16 (5), 7636-7650.
7) Zhou, Jingjing; Zhang, Lishi; He, Yuhang; Liu, Kexin; Zhang, Fangfang; Zhang, Hanru; Lu, Yaqi; Yang, Changyan; Wang, Zhaopeng; Fareed, Muhammad Subaan; Liang, Xiaolei;* Yan, Wenjin;* Wang, Kairong.* An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo. Eur J Med Chem 2021, 219, 113433.
四、发明专利
1.王凯荣；贺宇航；苏洁。小分子抗菌肽模拟物及应用，CN118005545A。
2.王凯荣；贺宇航；苏洁；李敏。基于Lugdunin的新型阳离子环肽抗生素，CN119331059A。
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