一、基本情况
郑治,医学博士;校聘教授,硕士生导师。主要从事心血管疾病机制探索及仿生药物递送载体研究。先后承担国家自然科学基金青年项目、中国博士后面上基金、湖南省自然科学基金青年项目等课题5项。以第一作者或通讯在J. Control. Release, Chem. Eng. J, Adv Healthc Mater等领域内杂志发表论文14篇,授权专利2项。
Email: zhengzhi@usc.edu.cn, 137959828@qq.com
二、研究领域
1.仿生药物递送系统:主要进行可注射水凝胶作为药物载体系统用于心肌梗死和骨修复的研究。
2. 心血管疾病的发病机制研究:动脉粥样硬化和心肌梗死的病理分子机制和防治的研究。
三、工作及学习经历
2024/9-至今,南华大学,药学院,讲师
2022/10-2024/9,南华大学,衡阳医学院,博士后
2019/9-2022/6,南华大学,衡阳医学院,博士
四、社会兼职
中国抗癌协会委员
五、教学工作
目前承担课程:药剂学、药用高分子材料学、药学前沿研讨等。
六、承担课题
1. 国家自然科学基金,载miR-199a-3p的抗氧化胶束-水凝胶复合体系构建及其重启心梗后心肌再生研究(82304429),2024.1-2026.12
2. 中国博士后面上项目,次序响应载OI抗氧化水凝胶构建及其重塑心脏能量代谢促进心肌修复的研究(2024M751350),2024.1-2025.12
3. 湖南省自然科学基金,基于序贯诱导软骨再生的仿生双交联水凝胶的构筑及其作用机制研究(2023JJ40570),2023.1-2025.12
4. 南华大学博士后科研启动基金,基于神经酰胺酶多肽水凝胶通过抑制心肌氧化应激促进梗死后心肌修复(220XQD106),2022.1-2025.12
七、代表性文章
1) Zheng, Z, Sun, J, Wang, J, He, S, Liu, Z, Xie, J, Yu, C. Y. *, & Wei, H*. Enhancing myocardial infarction treatment through bionic hydrogel-mediated spatial combination therapy via mtDNA-STING crosstalk modulation. J. Control. Release, 2024, 371, 570–587.
2) Zheng Z, Sun Jian, Wang Jun, He Suisui, Huang Yun, Yang Xu, Zhao Yuqi, Yu Cui-Yun*, Wei Hua*. A negative feedback bionic hydrogel reverses damaged cartilage microenvironment and induces targeted BMSCs differentiation for cartilage regeneration. Chemical Engineering Journal. 2023, Volume 473, 145228.
3) Zheng Z, Guo Z, Zhong F, Wang B, Liu L, Ma W, Yu CY*, Wei H*. A dual crosslinked hydrogel-mediated integrated peptides and BMSC therapy for myocardial regeneration. J. Control. Release. 2022, 7;347:127-142.
4) Zheng Z, Lei C, Liu H, Jiang M, Zhou Z, Zhao Y, Yu CY, Wei H. A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction. Advanced Healthcare Materials. 2022;11(19):e2200990.
5) Zheng Z, Tan Y, Li Y, Liu Y, Yi G, Yu CY*, Wei H*. Biotherapeutic-loaded injectable hydrogels as a synergistic strategy to support myocardial repair after myocardial infarction. J. Control. Release. 2021, 10;335:216-236.
6) Zheng Z, Yu C*, Wei H*. Injectable Hydrogels as Three-Dimensional Network Reservoirs for Osteoporosis Treatment. Tissue Eng Part B Rev. 2021 Oct;27(5):430-454.
7) Yuqi Zhao1, Zhi Zheng1*, Cui-Yun Yu*, and Hua Wei*. Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications. J Mater Chem. B. 2023 Dec 22;12(1):39-63.
8) Tan, Y, Nie, Y, ZhengWen, L, and Zheng, Z*. Comparative effectiveness of myocardial patches and intramyocardial injections in treating myocardial infarction with a MitoQ/hydrogel system. J Mater Chem. B, 2024 Jun 19;12(24):5838-5847.
9)Zhenqiu Liu1, Zhi Zheng1*, Jiahao Xie, Hua Wei*, and Cui-Yun Yu* Hydrogel-based Cardiac Patches for Myocardial Infarction Therapy: Recent Advances and Challenges. Materials Today bio. 2024,(接受)
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