一、基本情况
李宋娇，分析化学博士；校聘教授，硕士生导师。主要研究方向为分子荧光探针设计及生物医学成像应用研究。以第一作者或通讯作者在Analytical Chemistry、ACS Sensors、Chemical Communications、Sensors and Actuators B: Chemical等专业期刊上发表SCI收录论文10余篇。主持国家自然科学基金青年基金、湖南省自然科学基金青年基金、湖南省教育厅优秀青年基金、南华大学博士启动基金等多个科研项目。参与国家自然科学基金面上项目2项。
Email:lisongjiao@usc.edu.cn；QQ：1533974815
二、研究领域
1. 近红外分子荧光探针的合成及活体成像分析。
2.疾病相关诊断及治疗。
三、工作及学习经历
2021/9-至今，南华大学，药学院，校聘教授
四、教学工作
目前承担课程：无机化学B、化学原理等。
五、承担课题
1.国家自然科学基金青年基金，双靶向-双锁型近红外荧光探针的构建及其在脑胶质瘤精准成像中的应用（22304074），2024.1-2026.12，30万，在研，主持；
2. 湖南省青年基金项目，可激活靶向性近红外荧光探针的构建及在脑胶质瘤成像中的应用研究（2022JJ40358），2022.1-2024.12，5万元，在研，主持；
3. 湖南省教育厅优秀青年项目，近红外荧光探针的构建及其在癫痫疾病成像中的应用研究（22B0403），2023.1-2025.12，6万元，在研，主持。
4. 南华大学博士科研启动基金，可激活靶向性近红外荧光探针的构建及在脑胶质瘤成像中的应用研究，2022-2024，30万，在研，主持；
六、代表性文章
1) Songjiao Li, Peipei Wang, Miantai Ye, Ke Yang, Dan Cheng, Zhiqiang Mao, Longwei He, Zhihong Liu,A cysteine-activatable near-infrared fluorescent probe for dual-channel tracking lipid droplets and mitochondria in epilepsy, Analytical Chemistry，2023, 95, 11, 5133.(中科院一区Top，IF = 6.7)
2) Li, Songjiao; Song, Dan; Huang, Weijing; Li, Zhen; Liu, Zhihong ; In Situ Imaging of Cysteine in the Brains of Mice with Epilepsy by a Near-Infrared Emissive Fluorescent Probe, Analytical Chemistry, 2020, 92(3): 2802-2808. (中科院一区Top，IF = 6.7)
3)Li, Songjiao; Li, Yong-Fei; Liu, Hong-Wen; Zhou, Dong-Ye; Jiang, Wen-Li; Juan Ou-Yang; Li, Chun-Yan ; A Dual-Response Fluorescent Probe for the Detection of Viscosity and H2S and Its Application in Studying Their Cross-Talk Influence in Mitochondria, Analytical Chemistry, 2018, 90(15): 9418-9425. (中科院一区Top，IF = 6.7)
4)Li, Songjiao; Li, Chun-Yan; Li, Yong-Fei; Fei, Jun-Jie; Wu, Ping; Yang, Bing; Ou-Yang, Juan; Nie, Shi-Xin ; Facile and Sensitive Near-Infrared Fluorescence Probe for the Detection of Endogenous Alkaline Phosphatase Activity In Vivo, Analytical Chemistry, 2017, 89(12): 6854-6860. (中科院一区Top，IF = 6.7)
5) Li, Songjiao; Zhou, Dong-Ye; Li, Yongfei; Liu, Hong-Wen; Wu, Ping; Ou-Yang, Juan; Jiang, Wen-Li; Li, Chun-Yan ; Efficient Two-Photon Fluorescent Probe for Imaging of Nitric Oxide during Endoplasmic Reticulum Stress, ACS Sensors, 2018, 3, 2311 (中科院一区Top，IF = 8.2)
6) Peipei Wang, Ying Liu, Liang Tao, Dan Cheng, Longwei He, Songjiao Li*. Monitoring cysteine changes and assessing ferroptosis in diabetic mice with a lysosome-targeted near-infrared fluorescence probe. Sensors and Actuators B: Chemical, 2024,421,136549.（JCR1区，IF：8.0）
7) Songjiao Li, Ke Yang, Peipei Wang, Ying Liu, Dan Cheng, Longwei He.Monitoring heat stroke with a HClO-activatable near-infrared fluorescent probe. Sensors and Actuators B: Chemical 2023,385,133696.（JCR1区，IF：8.0）
8)Songjiao Li;Ke Yang;Ying Liu;Peipei Wang;Dan Cheng;Longwei He; An endoplasmic reticulum-targeted near-infrared probe for monitoring HClO fluctuation in diabetic mice and human blood, Sensors and Actuators B: Chemical, 2022, 379, 133253.（JCR1区，IF：8.0）
9) Ying Liu, Min Deng, Peipei Wang , Yin Liu ,Songjiao Li*, Longwei He.Visualizing lysosomes hypochlorous acid in Parkinson’s disease models by a novel fluorescent probe.Talanta,2024,279,126635.（JCR1区，IF：5.6）
10) Peipei Wang, Siwei Ai, Min Deng, Ying Liu, Yin Liu, Longwei He,Songjiao Li*. A lysosomal-targeted and viscosity-ultrasensitive near-infrared fluorescent probe for sensing viscosity in cells and a diabetic mice model.Talanta2024,278,126506.（JCR1区，IF：5.6）
11) Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng,Songjiao Li, Longwei He. Imaging peroxynitrite in endoplasmic reticulum stress and acute lung injury with a near-infrared fluorescent probe.Analytica Chimica Acta2024,1286,342050.（JCR1区，IF：5.7）
12) Songjiao Li, Peipei Wang, Ke Yang, Ying Liu, Dan Cheng, Longwei He, Construction of HClO activated near-infrared fluorescent probe for imaging hepatocellular carcinoma.Analytica Chimica Acta2023,1252,341009.（JCR1区，IF：5.7,高被引论文）
13)Songjiao Li,Peipei Wang, Wenqi Feng, Yunhui Xiang, Kun Dou, Zhihong Liu, Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift, Chemical communications, 2020, 56, 1050.（JCR1区，IF：6.065）