一、基本情况
何穗穗,化学博士;讲师,硕士生导师。主要从事生物医药传感器开发及肿瘤诊疗一体化应用研究。先后承担湖南省自然科学基金青年项目、湖南省卫健委项目、湖南省教育厅项目、衡阳市科技厅项目等。在Chemical Science、Analytical Chemistry、Chemical Engineering Journal、Analytica Chimica Acta等高水平杂志发表研究论文10余篇,授权专利4项。
Email:hess@usc.edu.cn,QQ:1301582553
二、研究领域
1. 生物医药传感器开发:新型多功能纳米传感器的设计合成及其用于疾病标志物、药物分子等的便携式即时检测研究。
2.肿瘤诊疗一体化应用:基于肿瘤微环境的纳米催化药物体系的构建及多模式靶向肿瘤诊疗研究。
三、工作及学习经历
2020/9-至今,南华大学,药学院,讲师
2015/9-2020/8,兰州大学,化学化工学院,博士
2011/9-2015/6,曲阜师范大学,化学与化工学院,本科
四、社会兼职
无
五、教学工作
目前承担课程:药物分析、分析化学、药学科研检索、生物药剂学与药物动力学、了解生活中的纳米科技等。指导本科生大学生创新训练计划项目、毕业论文等。
六、承担课题
1.湖南省自然科学基金青年项目,级联信号放大的温敏型自组装纳米复合探针用于肝癌便携式检测研究(2023JJ40529),2023.1-2025.12,5万;
2.湖南省卫生健康委员会项目,构建酸性解锁生物矿化配位聚合物载体用于肿瘤的原位双重催化治疗(202213024185),2022.1-2024.12,2万;
3.湖南省教育厅项目,CPs基纳米载体用于近红外光触发原位合成药物的协同抗癌性能研究(22C0204),2022.1-2024.12,1万;
4.南华大学博士科研启动基金,构建智能矿化配位聚合物纳米载体用于靶向线粒体的体内药物合成和化疗-光动力学联合肿瘤治疗(200XQD081),2021.01-2023.12,30万;
5.衡阳市科技局项目,谷胱甘肽响应型纳米探针的构建及其对癌症的便携式诊断和原位激活的化学动力治疗研究,2022.01-2024.12。
七、代表性文章
1)Li, Kailing1; Wang, Jun1; Wang, Jieqiong; Zheng, Zhi; Liu, Xinping; Wang, Jikai; Zhang, Chenjing;He, Suisui*; Wei, Hua*; Yu, Cui-Yun*;A Programmable Microfluidic Paper-Based Analytical Device for Simultaneous Colorimetric and Photothermal Visual Sensing of Multiple Enzyme Activities,Analytical Chemistry 2024,96(29):12181-12188.
2) Tian, Min1; Wang, Jun1; Xiang, Wang; Zheng, Zhi; Luo, Zhonghui; Jing, Shihan; Zheng, Yuxi; He, Suisui*; Wei, Hua*; Yu, Cui-Yun*; A dual-mode portable platform with spatiotemporal temperature–pressure signal readouts for ultrasensitive quantitative determination of cancer cells,Chemical Engineering Journal,2024,486: 150186.
3) Zhang, Jiaheng1; Wang, Jun1; Ouyang, Feijun; Zheng, Zhi; Huang, Xiaowan; Zhang, Haitao; He, Dongxiu;He, Suisui*; Wei, Hua*; Yu, Cui-Yun*; A smartphone-integrated portable platform based on polychromatic ratiometric fluorescent paper sensors for visual quantitative determination of norfloxacin,Analytica Chimica Acta,2023,1279: 341837.
4) He, Suisui; Lu, Siyu; Liu, Sha; Li, Tianrong; Li, Jieling; Sun, Shihao; Liu, Meilin; Liang, Kun; Fu, Xu; Chen, Fengjuan; Meng, Genping; Zhang, Lang; Hai, Jun*; Wang, Baodui*, Spatiotemporally controlled O2 and singlet oxygen self-sufficient nano photosensitizers enable the in vivo high-yield synthesis of drugs and efficient hypoxic tumor therapy, Chemical Science,2020,11(33): 8817-8827.
5)He, Suisui; Hai, Jun; Sun, Shihao; Lu, Siyu; Wang, Baodui*,Palladium Coordination Polymers Nanosheets: New Strategy for Sensitive Photothermal Detection of H2S, Analytical Chemistry,2019,91(16): 10823-10829.
6) Lu, Yu1; Wang, Song-Meng1;He, Suisui1; Huang, Qicheng1; Zhao, Cheng-Da; Yu, Shan; Jiang, Wei; Yao, Huan*; Wang, Li-Li*; and Yang, Liu-Pan*, An endo-functionalized molecular cage for selective potentiometric determination of creatinine,Chemical Science, 2024, https://doi.org/10.1039/D4SC04950K.
7)Li,Kailing1; Wang, Jun1;Liu,Li;Cao,Hui;Yang, Xu;Liu,Ying;Wang, Jikai;He, Suisui*; Wei, Hua*; Yu, Cui-Yun*; Pd(II)-based coordination polymer nanosheets for ratiometric colorimetric and photothermal dual-mode assay of serum alkaline phosphatase,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 299, 122802.
8)He, Suisui1; Chai, Jian1; Lu, Siyu; Mu, Xijiao; Liu, Ruitong; Wang, Qiang; Chen, Fengjuan; Li, Yuee*; Wang, Jingang; Wang, Baodui*, Solution-phase vertical growth of aligned NiCo2O4 nanosheet arrays on Au nanosheets with weakened oxygen-hydrogen bonds for photocatalytic oxygen evolution,Nanoscale,2020,12(10): 6195-6203.
9)He, Suisui; Hai, Jun; Li, Tianrong; Liu, Sha; Chen, Fengjuan*; Wang, Baodui*, Photochemical strategies for the green synthesis of ultrathin Au nanosheets using photoinduced free radical generation and their catalytic properties,Nanoscale,2018, 10(39): 18805-18811.
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