教育经历
1. 1995-1999,中国协和医科大学,细胞生物学,博士,导师:薛社普院士、刘德培院士
2. 1992-1995,厦门大学,海洋生物学,硕士,导师:许振祖教授
3. 1988-1992,西南师范大学,生物学,学士
工作经历
1. 2017- 今, 南华大学药学院,特聘教授,博导
2. 2013-2017,西南交通大学材料科学与工程学院,教授,硕导
3. 2009-2012,美国杜克大学医学中心,高级分析师 (Senior Analyst)
4. 2001-2009,美国国立卫生研究院环境卫生科学研究所,博士后研究员 (Research Fellow)
5. 2000-2001,美国希望城国家医学中心,博士后研究员(Research Associate)
人才计划、学术荣誉与奖励
1. 科技部高端外国专家计划(2021)
2. 四川省千人计划特聘专家(2014)
3. 美国药学和实验治疗协会博士后科学家奖 (ASPET Molecular Pharmacology Postdoctoral Scientist Award, 2007)
4. Sigma Xi科学研究协会成员(Member ofSigma Xi Scientific Research Society, 2005)
科研成果
1. C. Mo, L. Xiang,Y. Chen*,Advances in Injectable and Self-healing Polysaccharide Hydrogel Based on the SchiffBase Reaction,Macromolecular Rapid Communications, 2021, 42: 2100025.
2.L. Xiang,Y. Shao,Y. Chen*, Mitochondrial dysfunction and mitochondrion-targeted therapeutics in liver diseases,Journal of Drug Targeting,Published online: 09 Apr 2021.
3. G. Zeng,Y. Chen*, Surface Modification of Black Phosphorus-Based Nanomaterials in Biomedical Applications: Strategies and Recent Advances,Acta Biomaterialia, 2020, 118: 1.
4. Zhou Y, Liu X, Huang N,Chen Y*, Magnesium ion leachables induce a conversion of contractile vascular smooth muscle cells to an inflammatory phenotype.J Biomed Mater Res B Appl Biomater, 2019, 107 (4): 988-1001.
5.Chen Y,Choi S, Michelotti G, Chan I, Swiderska-Syn M, Karaca G, Xie G, Moylan C, Garibaldi F, Premont R, Suliman H, Piantadosi C, Diehl AM. Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism.Gastroenterology, 2012, 143(5): 1-11.他引次数:249
6.Chen Y, Ferguson SS, Negish M, Goldstein JA. Induction of humanCYP2C9by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor.J Pharmacol Exp Ther.2004, 308(2): 495-501.他引次数:341
7.Chen Y, Ferguson SS, Negishi M, Goldstein JA.Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in theCYP2C19promoter.Mol Pharmacol.2003, 64(2): 316-24.他引次数:239
8.ChenY,Goldstein JA. The Transcriptional Regulation of HumanCYP2CGenes,Curr Drug Metab.2009,10(6): 567-78.他引次数:214
9.ChenY, KisslingG, Negishi M, Goldstein JA, The Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Cross Talk with HNF4α to Synergistically Activate the HumanCYP2C9Promoter.J Pharmacol Exp Ther.2005, 314(3): 1125-33.他引次数:156
10. Wang X, Cheng J,Chen Y*, Camptothecin Delivered with the Retinol-Conjugated Nanomicelles Selectively Suppresses the Glycolysis of Hepatic Stellate Cells and Liver Fibrogenesis in Mice,Gastroenterology, 2017, 152(5): S1065–S1066.
11.Chen Y, Coulter S, Jetten AM, Goldstein JA.Identification of Human CYP2C8 as a Retinoid-Related Orphan Nuclear Receptor Target Gene.J Pharmacol Exp Ther.2009, 329(2): 192-201.
12. Rana R,Chen Y(共同一作),Ferguson SS, Kissling GE, Surapureddi S, Goldstein JA. Hepatocyte nuclear factor 4alpha regulates rifampicin-mediated induction of cyp2c genes in primary cultures of human hepatocytes.Drug metabolism & disposition:the biological fate of chemicals, (2010), 38(4):591-9.
13.陈渝萍,程江,张艳军,汪辛. 叶酸特异性靶向活化态肝星状细胞的聚合物纳米载体及其药用用途。中国专利号:ZL 2016 1 0018293.5. 授权公告日:2018.09.21。
14.陈渝萍,周玥华,刘星. 一种改良的大鼠胸主动脉血管平滑肌细胞的分离制备方法。中国专利号:ZL 2016 1 0148223.1. 授权公告日:2019.06.07.
15.陈渝萍,汪辛,程江,张艳军.一种接枝视黄醇聚合物及其作为载体的喜树碱化合物。中国专利号:ZL 2016 1 1127645.7. 授权公告日:2019.08.20.
16.陈渝萍, 张辉,曾国栋,赵昌波, 一种药物载体、兼具pH响应性和 HSC靶向性的载药纳米球、其制备方法和应用, 中国专利号:2018.8.23,ZL 201810965789.2.授权公告日:2020.12.01.
科研项目
17.科技部高端外国专家计划项目:“靶向肝癌纤维化微环境的新型抗肝癌药物的研究” (批准号G2021029011L),主持
18.国家自然科学基金面上项目:“应用纳米载体靶向性抑制肝脏星状细胞的糖酵解以治疗肝脏纤维化”(批准号 81371675),主持
19.国家自然科学基金重点项目:“时序功能性血管支架与植入周围环境的相互作用与调控 ”(批准号 81330031),主研
科研领域
1. 肝星状细胞的细胞代谢及肝纤维化的分子病理。
2. 肝纤维化/肝癌的靶向性纳米药物体系。
3. P450及药物的肝脏代谢。
4. 血管支架与平滑肌等血管细胞之间的相互作用。