一、基本情况
杨瑞阁，化学生物学博士，特聘教授，博士生导师。主要从事中药活性物质的发现、结构优化、生物活性及作用机制研究；药用植物资源的可持续利用与保护研究。先后承担中国自然科学基金青年科学基金、中国博士后面上、河南省重点研发与推广专项（科技攻关）等课题。在J. Med. Chem.、Eur. J. Med. Chem.、Chin. Chem. Lett.、J. Agri. Food Chem.等SCI期刊发表论文30余篇，其中ESI高被引论文4篇。
Email:yrggg@163.com
二、研究领域
1. 天然抗菌药物先导发现及机制研究。
2.药用植物资源保护研究。
三、社会兼职
Traditional Medicine Research期刊杂志青年编委。
四、教学工作
目前承担课程：研究生天然药物化学研究进展。
五、承担课题
1.国家自然科学基金青年科学基金，项目号：32001926，2021.01-2023.12
2.中国博士后面上项目，项目号：2019M652585，2019.01-2020.12
3.河南省重点研发与推广专项（科技攻关），项目号：232102111025，2023.01-2024.06
4.河南省重点研发与推广专项（科技攻关），项目号：192102110054，2019.01-2020.12
六、代表性文章
1) Ruige Yang,1 LipingCui,1 Shengnan Xu, Yan Zhong, Ting Xu, Jifeng Liu, Zhenwei Lan, Shangshang Qin, Yong Guo* Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus. J. Med. Chem. 2024, https://doi.org/10.1021/acs.jmedchem.4c01860.
2) Ting Xu,1 Xiaoting Yan,1 Ayue Kang, Longhua Yang, Xinhui Li, Yue Tian,Ruige Yang,* Shangshang Qin,* Yong Guo* Development of membrane-targeting fluorescent 2-phenyl-1H- phenanthro[9,10-d]imidazole-antimicrobial peptide mimic conjugates against methicillin- resistantStaphylococcus aureus.J. Med. Chem. 2024, 67(11), 9302−9317.
3) Hong Yao,1 Liping Cui,1 Hang Liu, Xueyu Li, Lin Shen,Ruige Yang,*, Shangshang Qin,*, Yong Guo* Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms. Chin. Chem. Lett. 2024, 108511.
4) Wanqing Cheng,1 Ting Xu,1 Liping Cui, Zihan Xue, Jifeng Liu,Ruige Yang,* Shangshang Qin,* Yong Guo* Discovery of Amphiphilic Xanthohumol Derivatives as Membrane- Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus.J. Med. Chem. 2023, 66(1), 962-975.
5) Ruige Yang,1 Enhua Hou,1 Wanqing Cheng, Xiaoting Yan, Tingting Zhang, Shihong Li, Hong Yao,* Jifeng Liu,* Yong Guo* Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistantStaphylococcus aureus (MRSA) infections.J. Med. Chem. 2022, 65(24), 16879-16892.
6) Ruige Yang,*,1, Zihan Xue1, Xinhui Li, Ting Xu, Yan Zhong, Songlin Hu, Shangshang Qin, Yong Guo* Novel natural osthole-inspired amphiphiles as membrane targeting antibacterials against methicillin-resistant Staphylococcus aureus (MRSA).Eur. J. Med. Chem. 2024, 271, 116449.
7) Zhiyan Liu,1 Meiyue Han,1 Xiaoting Yan, Wanqing Cheng, Zhenshuai Tang, Liping Cui,Ruige Yang,* Yong Guo* Design, synthesis, and biological evaluation of novel osthole-based isoxazoline derivatives as insecticide candidates. J. Agric. Food Chem. 2022, 70, 7921−7928.
8) Yong Guo, Meiyue Han, Yan Zhong, Xueyu Li, Songlin Hu, Ruige Yang* Discovery of Novel (+)-Nootkatone-Based Amine Derivatives as Potential Insecticide Candidates.J. Agric. Food Chem. 2024, 72, 17240−17247.